Antiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformis
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چکیده
منابع مشابه
Antiplasmodial activity of aryltetralone lignans from Holostylis reniformis.
Extracts from Holostylis reniformis were tested in vivo against Plasmodium berghei and in vitro against a chloroquine-resistant strain of Plasmodium falciparum. The hexane extract of the roots was the most active, causing 67% reduction of parasitemia in vivo. From this extract, six lignans, including a new (7'R,8S,8'S)-3',4'-methylenedioxy-4,5-dimethoxy-2,7'-cyclolignan-7-one, were isolated and...
متن کاملAntiplasmodial Activity of Aryltetralone
Antiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformis 1 2 Valter F. de Andrade-Neto, 1-3 Tito da Silva, 4 Lucia M. Xavier Lopes, 4* Virgílio E. do Rosário, 5 3 Fernando de Pilla Varotti, 1 and Antoniana U. Krettli 1 4 5 6 Laboratório de Malaria, Centro de Pesquisas René Rachou/FIOCRUZ, 30190-002, Belo Horizonte, 7 MG, Brazil; 1 Departamento de Parasitologia, Universidade F...
متن کامل4,5-seco-guaiane and a nine-membered sesquiterpene lactone from Holostylis reniformis.
Root extracts of Holostylis reniformis (Aristolochiaceae) yielded three new natural sesquiterpenes, a sesquiterpene with an unusual carbon skeleton, 4,5-seco-guaiane (7-epi-11-hydroxychabrolidione A, 1), a nine-membered lactone with new carbon skeleton (holostylactone, 2), and a new megastigmane [(6S,7E)-6,9-dihydroxy-10-(2'-hydroxy-ethoxy)-4,7-megastigmadien-3-one, 3], together with bulnesol a...
متن کاملThe antiplasmodial activity of isolates from Ajuga remota.
Ajuga remota is the most frequently used medicinal herb for malaria treatment in Kenya. Its two known isolates ajugarin-1 (1) and ergosterol-5,8-endoperoxide (3) and a new isolate 8-O-acetylharpagide (2) were evaluated for their in vitro antiplasmodial activity. Ajugarin-1 was moderately active, with an IC(50) of 23.0 +/- 3.0 microM, as compared to chloroquine (IC(50) = 0.041 +/- 0.003 microM) ...
متن کاملIn Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia
The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated. Peruvin was the most active compound on F32 stra...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2007
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01344-06